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Learn About Stroke
Facts
about the brain and ischemia
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The
cranium is a rigid box containing brain tissue (~85%), CSF (~10%)
and vessels (~5%)
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Normal
adult brain:
CBF of 50 to 55 mL/100 g per minute.
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Upper
threshold for ion pump failure: CBF falls to 18 mL/100 g per minute.
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Lower
threshold for ion pump failure: CBF of 8 mL/100 g per minute or less
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The
ischemic penumbra: Neurons that are functionally silent but
structurally intact and potentially salvageable
The
ischemic cascade
Numbers
of factors have an important role in the final destination of
ischemia, that is cell death. Full
understanding of this ischemic
cascade would
enlighten the path for
potentially effective treatment for
acute ischemic stroke.

The
autoregulation curve
The
brain has an autoregularity mechanism that would protect it when
there is a fall in the oxygen supply. These mechanisms involve blood
flow, intracranial pressure, systemic blood pressure, heart rate,
intracerebral blood vessel wall compliance and vasomotor reserve. This
mechanism would fail if exhausted.
Atherosclerosis
Atherosclerosis
carries high risk for stroke,
particularly if there is stenosis of the
internal carotid artery (higher risk with stenosis more than
70%). The studies showed that endarterectomy is effective
against stroke
occurrence and recurrence. See
how atherosclerosis affects vessels
Facts
about Stroke
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3rd most common cause
of mortality
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Affect
700,000 people in USA yearly
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5%
of victims are less
than age of 45 years
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Rate
in young is around
11-70 per 100,000 population
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Ischemic
stroke accounts for 80-85 % of all stroke
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Intracerebral
hemorrhage accounts for 15 % of all stroke
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Subarachnoid
hemorrhage is rare among Saudi population
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15
– 20 % ICU admissions are related to a vascular event
Survey
among Saudis in regards to stroke
A
small survey was conducted among Saudis visiting Riyadh Armed
Hospital
regarding thier knowledge about stroke. Here are the results:
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2
thirds recognized hemiparesis as a manifestation of stroke.
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30
% were unable to name a symptom or sign of stroke other than
hemiparesis.
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More
than 80 % would seek immediate medical help if come across an
event of stroke.
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More
than 80 % think of psychological stress as a major
"cause" for stroke.
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Only
34 % were able to name a correct complication to stroke.
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Only
30 % think that there might be a treatment for acute stroke,
but most of them can not mention one exactly.
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Only
40 % mentioned at least one correct stroke prophylaxis
measure.
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